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What is In Vitro Maturation (IVM)?

In vitro maturation (IVM) is when a woman’s eggs are collected and matured outside the body. This is done as part of an in vitro fertilization (IVF) procedure. A woman’s eggs (also called oocytes) are formed before she is born. These eggs stay in a resting state in her ovaries until puberty, when normal hormonal changes cause an egg to mature (ripen) and be released each month. When a woman undergoes IVF, she usually takes medicine to cause more than 1 egg to mature at the same time. These eggs are collected before they are released from the ovary, and are then paced with sperm in the laboratory in hopes of fertilization. In some cases, some or all of the oocytes (eggs) that are collected are not mature and ready to be fertilized. In years past, these eggs were not able to be used for IVF. Advances in science have allowed embryologists to take these immature eggs and sometimes “ripen” them in vitro (in the laboratory). This is called IVM. The eggs may be frozen for later use (as immature eggs, mature eggs, or embryos after they have been combined with sperm and fertilized). Or, they may be matured, fertilized, and placed into a woman’s uterus in hopes of pregnancy .

What is the IVM process in iran?

1. Baseline Testing 
For Fertility North patients, on day 2 of your cycle, you will have an ultrasound and a blood test.  

2. Hormone Stimulation
If you require hormonal stimulation, your Doctor will prescribe the ideal regimen for your circumstances.  Compared to conventional IVF, significantly less medication is required.  Occasional blood tests and/or ultrasound may be carried out to monitor follicle growth in your ovaries.

3. Trans Vaginal Oocyte Aspiration (TVOA) 
Using a general anaesthetic, your eggs will be collected from your ovaries using a very fine needle, under ultrasound guidance.

4. Egg Culture 
Once collected, your eggs will be cultured in our laboratory for 1 to 2 days.  This specially designed culture medium is supplemented with growth factors and hormones to help to eggs to mature.

5. Intracytoplasmic Sperm Injection (ICSI)
Once maturity has been assessed, each mature egg is very carefully injected by one of our highly trained 
Embryologists with a single, healthy sperm using a microscopic glass needle.   

6. Embryo Culture 
The morning following IVF, the Embryologists will assess your eggs for fertilisation.  Keeping you advised along the way, your embryos will then be grown in the laboratory for up to six days.  All suitable embryos will then be frozen, to be used in a  Frozen Embryo Transfer Cycle, in which the uterine environment will be optimised to increase your chance of success. 

Who is IVM suitable for?

Iranian Doctor Recommend In Vitro Maturation for you if: 
You are known to have polycystic ovarian syndrome (PCOS) 
There are problems in treating women with fertility enhancing drugs for IVF, as the PCOS ovary can be highly sensitive. As a result, the drugs may have little effect on follicle/egg development, or conversely the ovary may over-respond producing too may follicles. The second of these two scenarios often results in a condition known as ovarian hyperstimulation syndrome (OHSS).  
You have had previous treatment cycle/s cancelled due to ovarian hyperstimulation syndrome (OHSS)
Ovarian Hyperstimulation Syndrome is a condition in which the ovaries over-respond to the hormonal stimulation used in conventional fertility treatments.  This condition is very serious and can result in long periods of hospitalisation and, in severe cases, deaths have been reported. 
You have been diagnosed with cancer 
IVM treatment can also provide a safe alternate treatment option where fertility-enhancing drugs are not advised such as for fertility preservation prior to some cancer treatments. IVM can provide a fast and safe method to freeze eggs or embryos quickly, so as not to delay chemo/radiotherapy. 

You have Ovary Resistant Syndrome, also known as Savage Syndrome 
The ovaries of patients with this condition are resistant to the hormonal stimulation protocols used in conventional fertility treatments.  IVM can be used to successfully treat these patients

In-vitro maturation (IVM) VS In vitro fertilization (IVF)

In vitro fertilization is a complex process where mature eggs are extracted from a woman’s ovaries. From there, sperm is combined with the eggs at a lab or clinic to encourage fertilization. The newly formed embryo is then implanted into the uterus to start a pregnancy. Any remaining embryos are frozen for other cycles, if necessary. In vitro maturation takes the process a step further by extracting immature eggs. The eggs are both matured and fertilized out of the body. This means that clinics can freeze immature eggs for future use .

IVM cost in Iran

IVM is cheaper than IVF because it is more likely that no fertility drugs are needed. Fertility drugs used in IVF treatment can sometimes cost up to £2,000 in the UK, which contributes to the higher cost of IVF. On the other hand, the price of IVM treatment globally varies from country to country. Treatment costs vary significantly in the UK, USA or Asia. The current cost for an IVM cycle in the United States may range from $5,000 to $7,000 .
Currently, among the Asian countries, Iranian clinics offer higher quality and more affordable infertility treatments. The operating cost of IVM in Iran is more affordable and is less than a third of its price in the neighboring countries of the region and even less compared to its costs in England or America, which makes Iran a desirable country to own. IVM surgery.

What are the risks of IVM?

The risks of In Vitro Maturation are very similar to those experienced during conventional IVF, however, the fact that Controlled Ovarian Hyperstimulation (COH) is not used during IVM, the risk of developing OHSS is all but removed.

Likewise, evidence indicates that the success rates of IVM are very similar to that of conventional IVF. In Vitro Maturation has also been demonstrated to be particularly successful in patients with PCOS.

It is important to note that IVM is not suitable for all people – your Doctor will discuss whether it is suitable for you, in accordance with your individual circumstances

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